Are the reconstitution, mixing, and diluting of Group 2 and 3 hazardous drugs allowed under an assessment of risk?

The option stating that reconstitution, mixing, and diluting of Group 2 and 3 hazardous drugs are allowed under an assessment of risk is correct because USP Chapter <800> emphasizes a risk-based approach when handling hazardous drugs. This means that while certain practices can pose risks, they can be conducted safely with appropriate precautions and risk mitigation strategies in place.

In practice, when healthcare personnel are involved in processes such as reconstitution, mixing, or diluting hazardous drugs, they should follow strict safety protocols. These may include using personal protective equipment (PPE), working in designated areas such as a compounding aseptic containment isolator (CACI), and employing engineering controls to minimize exposure. The assessment of risk enables healthcare facilities to evaluate the specific situations and take necessary precautions, thus allowing these actions to be safely performed in compliance with USP guidelines.

This approach aligns with the overarching goal of ensuring safety for healthcare workers, patients, and the environment when handling hazardous medications.