Can a Laminar Airflow Workbench (LAFW) be used for compounding an antineoplastic HD?

A Laminar Airflow Workbench (LAFW) is not an appropriate environment for compounding antineoplastic hazardous drugs (HDs) due to its design and functionality. LAFWs are designed to provide a clean and sterile environment primarily for non-hazardous applications and do not ensure adequate protection against harmful exposures inherent in handling antineoplastic drugs.

The primary concern when compounding antineoplastic HDs is protecting the health care worker from exposure to these highly potent and potentially toxic agents. LAFWs do not have the necessary containment features that a Class II Biological Safety Cabinet (BSC) or a Compounding Aseptic Containment Isolator (CACI) provides, which are specifically designed to prevent the exposure of workers to airborne contaminants and provide effective protection from hazardous drugs.

In light of this information, the conclusion that a LAFW does not adequately protect workers when compounding antineoplastic HDs is validated. Therefore, it is essential to use appropriate equipment that meets the safety standards outlined in USP 800 for handling hazardous drugs to protect both personnel and the environment from exposure.