Can the air changes per hour (ACPH) in the C-SEC be set below the minimum requirement when the area is not in use?

Maintaining air changes per hour (ACPH) in the compounding secondary engineering controls (C-SEC) is crucial for ensuring a safe environment, especially when handling hazardous drugs. The minimum ACPH requirement is established in USP 800 to ensure adequate ventilation and air quality, which is vital for protecting personnel and maintaining the integrity of the compounding process.

Even when the area is not in use, it is essential to maintain the minimum air exchange to prevent the accumulation of contaminants and to keep the environment ready for immediate use. Reducing the air changes below the required level can compromise safety and put individuals at risk, as hazardous substances can linger in the air. Therefore, adherence to the established ACPH is non-negotiable for compliance with safety standards.

In essence, maintaining appropriate air exchange at all times, regardless of usage, is critical for ensuring that the C-SEC meets the necessary safety regulations and protects the health of personnel involved in compounding operations. This commitment to safety forms the basis of the correct answer.