How should sterile compounding of hazardous drugs be performed?

Sterile compounding of hazardous drugs must be performed in designated compounding areas that are specifically equipped with appropriate containment devices. This requirement stems from the need to protect healthcare workers, patients, and the environment from potential exposure to hazardous drugs, which can pose significant health risks. Containment devices, such as Class II biological safety cabinets or compounding aseptic containment isolators, are designed to minimize the risk of drug exposure and to ensure that the compounding process is performed in a controlled environment.

Designated compounding areas are equipped to meet stringent guidelines regarding air quality, ventilation, and cleanliness, which are essential in reducing the potential for contamination and ensuring the safety of the compounding process. Following USP <800> guidelines is crucial for maintaining safe practices in handling hazardous drugs.

The other options would not provide the necessary safeguards required when dealing with hazardous materials, as performing compounding in unrestricted areas or general clean rooms does not offer the specialized protection these drugs require.