What incidents require immediate reporting under USP 800 guidelines?

The correct response identifies that any spills or exposures related to hazardous drugs necessitate immediate reporting under USP 800 guidelines. This is critical because USP 800 was developed to ensure safe handling of hazardous drugs, protecting both healthcare workers and the environment from potential harm. Spills and exposures can lead to contamination and significant health risks, not only to the person directly involved but also to other staff and patients in the vicinity. Prompt reporting allows for immediate corrective actions to mitigate the risks associated with those hazardous materials.

The other scenarios mentioned do not imply the same level of urgency. Routine audits and deficiencies found during audits, while important for maintaining safety and compliance, do not present immediate risk to health and safety and therefore are not categorized for immediate reporting. Similarly, minor incidents not involving drugs may not pose significant hazards and thus can follow standard reporting protocols rather than necessitating immediate action.