What is a potential risk when using automated machines for antineoplastic HDs?

Using automated machines for handling antineoplastic hazardous drugs (HDs) involves specific risks that need careful consideration. One of the primary concerns is the potential creation of powdered contaminants. Automated systems can generate aerosols or fine particles during drug manipulation, which may escape into the environment if not properly contained. This risk is particularly critical for antineoplastic drugs due to their toxic effects, including potential carcinogenicity, teratogenicity, and mutagenicity.

The generation of powdered contaminants can pose severe health risks to pharmacy staff, other healthcare workers, and patients if exposure occurs. Therefore, it is essential that the use of automated machines is accompanied by adequate engineering controls, including proper containment and ventilation systems, to minimize these risks and ensure safety in the handling of hazardous drugs. Ensuring that sterile compounding practices are followed meticulously helps to mitigate the potential hazards associated with automated preparation of antineoplastic agents.