What is the minimum air changes per hour required for negative pressure compounding areas?

The minimum air changes per hour required for negative pressure compounding areas is established to maintain a safe environment for both the personnel and the surrounding areas. Negative pressure rooms are designed to contain hazardous substances and prevent their escape into adjacent areas. The requirement for 12 air changes per hour helps ensure that any potentially harmful contaminants are effectively diluted and removed from the space.

This level of air exchange is crucial because it creates a continuous flow of fresh air into the area while exhausting air that may have become contaminated. This high turnover rate not only mitigates exposure risks but also helps maintain appropriate facility standards for the safe handling of hazardous drugs, ensuring compliance with the guidelines set forth in USP Chapter 800 and other regulatory standards. The focus on maintaining high air change rates is central to protecting healthcare workers and patients from the risks associated with hazardous compounds.