When is it essential to use a Compounding Aseptic Containment Isolator (CACI)?

The use of a Compounding Aseptic Containment Isolator (CACI) is essential when handling hazardous drugs due to the unique risks that these substances pose to both the compounder and the environment. Hazardous drugs can include antineoplastics, hormones, and certain antiviral medications that can have harmful effects on the body if inhaled, absorbed through the skin, or otherwise improperly handled.

A CACI is specifically designed to maintain a sterile environment while also containing any hazardous particulates or vapors. It employs high-efficiency particulate air (HEPA) filters to ensure that air quality remains uncompromised, thereby minimizing exposure to personnel and preventing contamination of the drug product. This system protects the operator by providing a physical barrier, significantly reducing the risk of exposure while ensuring compliance with safety standards as set forth by USP Chapter <800>.

In contrast, other types of compounding, including non-hazardous materials, do not require the same stringent containment measures, since they do not carry the risks associated with handling hazardous drugs. Therefore, the necessity of utilizing a CACI is specifically linked to the handling of hazardous substances to safeguard health and safety during compounding processes.