Which factor is critical in the safe handling of hazardous drugs?

The critical factor in the safe handling of hazardous drugs is the use of personal protective equipment (PPE). The primary role of PPE is to protect healthcare workers and others involved in drug handling from exposure to hazardous substances, which can pose significant health risks. PPE includes items like gloves, gowns, masks, and goggles, which create a barrier against direct contact, inhalation, or accidental exposure to hazardous drugs.

In environments where these drugs are compounded or administered, the effective use of PPE is part of the broader safety protocols outlined in USP 800, which includes engineering controls, work practices, and the use of safety devices. Proper training on the use of PPE and the implementation of safety measures contribute to a safer workplace and help minimize the risk of contamination or exposure, thereby ensuring compliance with safety standards in healthcare.

Factors like drug popularity, cost, and manufacturer reputation may play roles in decision-making regarding drug procurement or usage but do not directly affect the safety practices related to the handling of hazardous medications. Thus, while those factors are relevant in a broader context, they do not address the immediate concern of safe handling practices.