Which type of PPE is essential when compounding HDs in a negative pressure area?

The correct choice is gown and shoe covers because when compounding hazardous drugs (HDs) in a negative pressure area, it is crucial to wear personal protective equipment (PPE) designed to minimize exposure and protect the individual from contamination. Gowns are specifically designed to resist permeation by HDs and provide a barrier to protect the skin and clothing from spills or splashes.

Shoe covers further enhance safety by preventing the tracking of contaminants from the pharmacy environment into other areas. The use of these specific items ensures that the risk of exposure is minimized, adhering to the guidelines outlined in USP <800>, which addresses the handling of HDs to protect health care workers, patients, and the environment.

Other options, such as a basic lab coat or regular clothing, do not provide adequate protection against the risks associated with handling hazardous medications. A face shield alone does not cover the entire body, leaving areas vulnerable to potential exposure during compounding procedures. Thus, the appropriate use of gowns and shoe covers aligns with safety protocols necessary for compounding HDs safely.